![]() ![]() Thus, in agreement with preclinical studies, we show that recreational use of dAMPH in human subjects is associated with dopaminergic system dysfunction. Finally, the lower D2/3 availability, the more pleasant the dAMPH administration was experienced by control subjects, but not by dAMPH users. In dAMPH users we further observed a blunted DA release and DA functionality to an acute dAMPH challenge, as well as a blunted subjective response. dAMPH users displayed significantly lower striatal DA D2/3 receptor binding compared to healthy controls. Also, the subjective responses to the challenge were determined. We assessed baseline D2/3 receptor availability, in addition to changes in DA release using single-photon emission computed tomography (SPECT) and DA functionality using pharmacological magnetic resonance imaging (phMRI) following a dAMPH challenge. Here, we studied the dopaminergic system at multiple physiological levels in recreational dAMPH users and age, gender and IQ-matched dAMPH-naïve healthy controls. Although animal studies have shown neurotoxic effects of dAMPH on the dopaminergic system, little is known about such effects on the human brain. Dexamphetamine (dAMPH) is a stimulant drug that is widely used recreationally as well as for treatment of attention deficit hyperactivity disorder (ADHD). ![]()
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